I saw in the news section of this website that Sonic Mega Collection will have many Sonic games on it, as well as Sonic the Hedgehog 3 and Sonic & Knuckles. Will we be able to make them program together to get Sonic 3 & Knuckles? Will we be able to play as Knuckles in Sonic the Hedgehog 2 also?
Yes there is a good chance you will.